![]() The increase in the prevalence of chronic diseases and the development of therapeutic drugs has resulted in increased drug exposure in the population. They encouraged publication after the decision to publish was made by the authors.Ĭompeting interests: The authors have declared that no competing interests exist. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Request for data access should be directed to the institutional review boards of Hanyang University Hospital ( Jungang University Hospital ( and Chungbuk National University Hospital ( This research was supported by a grant for the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI19C0218) the National Research Foundation of Korea (NRF) grant funded by the government of Korea (2020R1F1A1069087) and a research grant from the Korea Institute of Drug Safety & Risk Management (2015-0002). Access to the de-identified data are available for researchers who meet the criteria for access to confidential data. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: The data in this study cannot be shared publicly because of the limigations imposed by the study’s ethics approval. Received: DecemAccepted: JPublished: September 19, 2022Ĭopyright: © 2022 Kang et al. PLoS ONE 17(9):Įditor: Masaki Mogi, Ehime University Graduate School of Medicine, JAPAN (2022) Adverse drug events leading to emergency department visits: A multicenter observational study in Korea. The findings suggest that an age-specific approach should be adopted in the preventive strategies to reduce adverse drug events.Ĭitation: Kang M-G, Lee J-Y, Woo S-I, Kim K-S, Jung J-W, Lim TH, et al. Adverse drug event features differ substantially according to age group. Causative drugs of adverse drug events varied considerably depending on age group. The proportion of adverse drug event-related emergency department visits that were preventable was 15.3%. Serious adverse drug events, hospitalizations, and adverse drug event-related deaths occurred more frequently in the elderly than in adults or children/adolescents. Side effects were the most common type of adverse drug events across age groups, although main types differed substantially depending on age. Comorbidities such as diabetes, chronic kidney disease, chronic liver disease, and malignancies were also significantly associated with adverse drug event-related emergency department visits. Multivariate logistic regression analysis revealed that compared to non- adverse drug event-related cases, adverse drug event-related emergency department visitors were more likely to be female (60.6% vs. ![]() Adverse drug event-related emergency department visits were more likely to be female and older. Of 59,428 emergency department visits, 2,104 (3.5%) were adverse drug event-related. The cause, severity, preventability, and causative drug(s) of each adverse drug event were analyzed and compared between age groups (children/adolescents, adults, and the elderly ). The proportion of adverse drug events among total emergency department visits was calculated. ![]() We reviewed emergency department medical records obtained from three university hospitals between July 2014 and December 2014. This multicenter retrospective observational study evaluated the prevalence and features of adverse drug event-related emergency department visits across ages. Systematic evaluation of adverse drug events leading to emergency department visits by age is lacking. Adverse drug events are significant causes of emergency department visits. ![]()
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